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Psicothema was founded in Asturias (northern Spain) in 1989, and is published jointly by the Psychology Faculty of the University of Oviedo and the Psychological Association of the Principality of Asturias (Colegio Oficial de Psicología del Principado de Asturias).
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Psicothema, 2010. Vol. Vol. 22 (nº 4). 887-892




Diferencias sexuales en el efecto de privación alcohólica en ratas

David García-Burgos, Tatiana Manrique Zuluaga*, Milagros Gallo Torre y Felisa González Reyes

Universidad de Granada y * Parque Tecnológico de Ciencias de la Salud

Son escasos los estudios que han investigado la relación entre edad de inicio en el consumo de alcohol a edades tempranas y riesgo de recaída en la adultez, que puede además ser mayor en hembras según revelan estudios con ratas. El presente estudio evalúa el efecto de privación alcohólica (ADE en inglés) en ratas adultas de ambos sexos que comenzaron la ingesta alcohólica durante la preadolescencia o adolescencia. Durante las exposiciones recibieron libre acceso a agua y a soluciones de etanol al 5, 10 y 20% (v/v). Los efectos de la edad y sexo sobre el ADE en ratas adultas se evaluaron tras repetidos períodos de abstinencia. Los resultados mostraron que solo las hembras incrementaron el consumo de etanol tras la segunda y tercera privación (mostrando ADE), con independencia de la edad de inicio de consumo.

Sex differences in the alcohol deprivation effect in rats. Few studies have investigated the relationship between early onset of alcohol drinking and relapse in adulthood, which may be larger in females, as revealed by studies using rats as subjects. The present study assesses the alcohol deprivation effect (ADE) in adult rats of both sexes that began alcohol consumption during preadolescence or adolescence. Female and male Wistar rats received free-choice access to water, 5, 10 and 20% (v/v) ethanol solutions during the ethanol exposures. The effects of age and sex on ADE in adult rats were assessed after repeated periods of abstinence. The results showed that female but not male rats increased ethanol intake after the second and third deprivation (showing ADE), irrespective of the onset-age of alcohol drinking.

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